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Oregon

IMB Retreat 2008

Compositive image of adult mouse cerebellar folia duplicated, rotated, and reflected to generate two-dimensional symmetry. The cyclin-dependent kinase inhibitor and tumor suppressor p27kip1 (p27) is required for proper cell cycle exit timing in cerebellar granule cells. MADM, a genetic mosaic system, achieves p27 inactivation and simultaneous labeling in sporadic cells in mice, closely mimicking physiologic loss of heterozygosity. Mosaic knockout of p27 in granule cells results in drastic expansion of p27-/- cells (green) compared to p27+/+ cells (red) within the same animal. 
Zong Lab

Recent IMB Research Publications

Loss of seven-up from Drosophila R1/R6 photoreceptors reveals a stochastic fate choice that is normally biased by Notch
Development 135(4):707-15.
Herman Lab

Direct Spectroscopic Study of Reconstituted Transcription Complexes Reveals That Intrinsic Termination Is Driven Primarily by Thermodynamic Destabilization of the Nucleic Acid Framework.
J. Biol. Chem. 283:3537-49
von Hippel Lab

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