The Institute of Molecular Biology at the University of Oregon is an interdisciplinary research community, founded in 1959, dedicated to investigating biological questions at the molecular level. Our collaborative and interactive Institute brings together--from the Departments of Biology, Chemistry, and Physics -- scientists using diverse approaches and state-of-the-art facilities. This rich research environment provides exceptional training opportunities for young scientists.
Compositive image of adult mouse cerebellar folia duplicated, rotated, and reflected to generate two-dimensional symmetry. The cyclin-dependent kinase inhibitor and tumor suppressor p27kip1 (p27) is required for proper cell cycle exit timing in cerebellar granule cells. MADM, a genetic mosaic system, achieves p27 inactivation and simultaneous labeling in sporadic cells in mice, closely mimicking physiologic loss of heterozygosity. Mosaic knockout of p27 in granule cells results in drastic expansion of p27-/- cells (green) compared to p27+/+ cells (red) within the same animal. Zong Lab.
Recent IMB Research Publications
Heterochromatin protein 1 forms distinct complexes to direct histone deacetylation and DNA methylation Nat Struct Mol Biol May 2012News & Views
Selker Lab
RNA binding and RNA remodeling activities of the half-a-tetratricopeptide (HAT) protein HCF107 underlie its effects on gene expressionBarkan Lab
IMB News
Eric Selker has been elected to the National Academy of Sciences! Read more...
The 2011 IMB Newsletter is now available.
Hui Zong has been awarded the Richard T. Jones New Investigator Award from the Medical Research Foundation
Chris Doe has been awarded the Medical Research Foundation Discovery Award
297 Klamath Hall